European heavyweights Barcelona, Bayern Munich, Juventus and Paris St Germain all maintained their leads and Benfica toppled Sporting Lisbon.
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The 46-year-old Norwegian has guided United to 14 wins in 19 matches in all competitions as caretaker boss since replacing the sacked Jose Mourinho in December.
Barcelona's lead at the top of La Liga was cut after a second consecutive defeat and LeicesterCity's improbable march towards the Premier League title showed no sign of slowing as they won a fifth straight match. Juventus stayed six points clear of Napoli after Italy's top two both won and Bayern Munich extended their Bundesliga lead to seven points. Here is a summary of results from football matches played across Europe over the weekend.
Chelsea have not given up hope of signing unsettled Manchester United forward Wayne Rooney, Blues manager Jose Mourinho has said.
Raphael Varane converted two corners as a second-string Real Madrid began the defence of their King's Cup crown with a 4-1 victory against third-tier part-timers Cornella on Wednesday.
Striker Costa ends second spell at Atletico Madrid.
English football clubs splurged on the final day of the transfer window, laying out 210 million pounds to take total gross spending to a record-high 1.4 billion pounds as the Premier League again flexed its unrivalled financial muscles.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Manchester City's leading goalscorer Sergio Aguero is expected to be out for a month with a hamstring injury, the club's manager Manuel Pellegrini said on Friday.
Barcelona were held to a frustrating 0-0 draw at Olympique Lyonnais in their Champions League last-16 first leg on Tuesday as both sides remained unbeaten in this season's competition.
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The 41-year-old has made 640 appearances in Serie A, within striking distance of the 647-game record of AC Milan defender Paolo Maldini. Buffon began his career at Parma before moving to the Turin club in 2001.
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.
On a day of frenetic spending that took the Premier League total to a record far above one billion pounds ($1.29 billion), Antonio Conte's side also missed out on two of their other targets - Alex Oxlade-Chamberlain and Fernando Llorente.
Check out the top footballers of the weekend...
This and more from the happenings in the world of football
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Lionel Messi reclaimed the FIFA Ballon d'Or award for the world player of the year on Monday from his great rival Cristiano Ronaldo who had walked off with the award for the previous two years.
Champions Bayern Munich demolished VfB Stuttgart 4-0 on Saturday with all the goals coming in the first half as they increased their lead to eight points and stayed on course for a record fourth consecutive title on a day of red cards in the Bundesliga.
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Centre forward Eder, who scored the winning goal in the Euro 2016 final against France, was among 10 players from that squad omitted from Santos's list. Other unlucky players included midfielders Andre Gomes and Renato Sanches, forward Nani and defender Eliseu.
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Gijon spoiled Asier Illarramendi's return to Real Sociedad's midfield after rejoining from Real Madrid this week when they held the Basque club, coached by Scot David Moyes, to a 0-0 draw in San Sebastian.
Liverpool regained their place at the top of the English Premier League with a 2-0 win at Cardiff City on Sunday that restored their two-point lead over Manchester City
Atletico Madrid suffered a first defeat in 13 games in all competitions as they lost 1-0 at home to Villarreal on Tuesday after a late strike from substitute Roberto Soriano.
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There was the usual frenzy of last-minute deals as the English Premier League brought the curtain down on another bumper European transfer window in which Manchester City again flexed their financial muscle as the continent's top spenders.
This and more from the happenings in the world of football
Having absorbed the body blow of losing striker Radamel Falcao in the close season, Atletico Madrid have emerged as genuine contenders to break the title stranglehold of Real Madrid and Barcelona.
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Manchester United humbled Manchester City 4-2 in the continent's big derby of the weekend.
Following is a match by match look at the English Premier League's weekend fixtures:
A huge shock is on the cards in British football as a rank outsider is threatening to gatecrash the millionaire favourites. But it is Scottish hopefuls Aberdeen and not English league leaders Leicester who have bridged the biggest financial gulf.
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Leeds United manager Marcelo Bielsa asked his players to allow the visitors to score unchallenged when the game was restarted.
Barcelona's Lionel Messi and Luis Suarez secured victory over nine-man Atletico Madrid in La Liga's top of the table clash, while Juventus won a 12th straight Serie A game to stay hot on the heels of leaders Napoli.
News of all that transpired on and off the football field.